Download A Short History of Medical Genetics by Peter S. Harper PDF

By Peter S. Harper

ISBN-10: 0195187504

ISBN-13: 9780195187502

ISBN-10: 0199720134

ISBN-13: 9780199720132

An eminent geneticist, veteran writer, OMMG sequence Editor, and famous archivist, Peter Harper offers a full of life account of ways our rules and data approximately human genetics have constructed during the last century from the point of view of somebody contained in the box with a deep curiosity in its historic points. Dr. Harper has researched the historical past of genetics and has had own touch with a number of key figures whose stories and studies expand again 50 years, and he has interviewed and recorded conversations with lots of those vital geneticists. hence, instead of being a standard historical past, this e-book transmits the essence of the tips and the folks concerned and the way they interacted in advancing- and infrequently retarding- the sphere. From the origins of human genetics; throughout the contributions of Darwin, Mendel, and different giants; the id of the 1st human chromosome abnormalities; and up during the final touch of the Human Genome undertaking, this Short History is written within the author's attribute transparent and private kind, which appeals to geneticists and to all these drawn to the tale of human genetics.

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Family, mentioned earlier in this chapter. He further recognized that the age at onset in such families might be closely correlated, allowing those past a critical age to be reassured. ” He was here clearly recognizing the difference between what we now describe as “Mendelian” and “multifactorial” disorders. Adams cited gout as an example of a predisposition, especially when it follows “intemperate or sedentary indulgences”: “Where the hereditary susceptibility amounts only to a predisposition, some external causes are well known.

It is fair to say that Lamarckian inheritance of acquired characters never recovered scientifically from Weismann’s critique. His second paper included an assessment of human “mutilations,” including circumcision, body piercing, and foot binding; he concluded that there was no convincing evidence that any of these acquired characters had an effect on descendants. He was equally skeptical of “maternal impressions” in pregnancy as a possible cause of cleft lip and other malformations. 17 It provided the final advance in the understanding of heredity before the rediscovery of Mendel’s work, and it ensured that Mendel would have a more favorable reception in 1900 than would have been the case had his experiments become immediately known to the wider scientific community in 1866.

Born in London and working as an apothecary, Adams was the first to distinguish the categories of genetic disorder that we now recognize as “dominant” and “recessive” in inheritance. (A) Portrait of Joseph Adams. (B) Title page of Adams’s 1814 book (see text for details). ) FIGURE Adams distinguished hereditary disorders, which are passed to descendants, many of which would prove to be dominantly inherited, from familial conditions, which are present in sibs but not transmitted to offspring. ” Adams distinguished further between congenital disorders, which are present from birth, and disposition, in which onset is later and the condition is progressive.

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A Short History of Medical Genetics by Peter S. Harper

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