By Vinod Labhasetwar, Diandra L. Leslie-Pelecky
An outline of nanotechnology and its potentialThe box of nanotechnology is present process fast advancements on many fronts. This reference offers a accomplished evaluation of assorted nanotechnologies that allows you to their biomedical purposes. With chapters contributed via exclusive scientists from assorted disciplines, Biomedical purposes of Nanotechnology: studies fresh advances within the designing of varied nanotechnologies in keeping with nucleic acids, polymers, biomaterials, and metals Discusses biomedical nanotechnology in parts resembling drug and gene supply Covers complex points of imaging and diagnostics contains a bankruptcy at the factor of nanotoxicologyComplete with figures and tables, this can be a functional, hands-on reference booklet for researchers in pharmaceutical and biotech industries, biomedical engineers, pharmaceutical scientists, pharmacologists, and fabrics scientists in addition to for the policymakers who have to comprehend the potential for nanotechnology. it's also a great source publication for graduate-level scholars in pharmaceutical sciences, biomedical engineering, and different fields within which nanotechnology is enjoying an more and more vital function.
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Chien CL, Sun L, Tanase M, Bauer LA, Hulgren A, Silevitch DM, Meyer GJ, Searson PC, Reich DH. Electrodeposited magnetic nanowires: Arrays, ﬁeld-induced assembly, and surface functionalization. J Magn Magn Mater 2002;249:146–155. 24. Reich DH, Bauer LA, Tanase M, Hultgren A, Chen CS, Meyer GJ. Biological applications of multifunctional magnetic nanowires (invited). J Appl Phys 2003;93:7275. 25. Tanase M, Felton EJ, Gray DS, Hultgren A, Chen CS, Reich DH. Assembly of multicellular constructs and microarrays of cells using magnetic nanowires.
The obvious predicition is that below the saturation limit, any measure that increases the drug concentration at the target cell surface at a given drug dose will increase the response to the drug. Luo and Saltzman have veriﬁed this prediction for gene delivery and have substantiated it with theoretical analysis by associating vectors with dense silica particles that sedimented vectors on the cell surfaces. Generalizing their observations, one can state that physical VECTOR LOCALIZATION BY MAGNETIC FORCE (MAGNETOFECTION) 35 force acting on vectors directed in a manner to overcome motion away from the target enhances the delivery process.
In a biomaterial scientist’s view, viruses are nanoparticles that are stable enough (biocompatible) during the delivery phase, yet their constituents are assembled in a manner labile enough to allow disassembly and biological processing once they have reached their target. It is not surprising that synthetic constructs for nucleic acid delivery are also recognized as foreign by the host organism. This recognition takes place on a systemic level during the extracellular delivery phase but also at the target cell level.
Biomedical Applications of Nanotechnology by Vinod Labhasetwar, Diandra L. Leslie-Pelecky