By Giuseppe Perale, Jöns Hilborn
Bioresorbable Polymers for Biomedical purposes: From basics to Translational Medicine presents readers with an outline of bioresorbable polymeric fabrics within the biomedical box. an invaluable source for fabrics scientists in and academia, delivering details at the basics and issues, synthesis and processing, and the scientific and R and D purposes of bioresorbable polymers for biomedical applications.
- Focuses on biomedical purposes of bioresorbable polymers
- Features a entire diversity of themes together with basics, synthesis, processing, and applications
- Provides balanced insurance of the sector with contributions from academia and industry
- Includes medical and R and D purposes of bioresorbable polymers for biomedical applications
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Extra resources for Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine
MFI is an indirect measure of molecular weight, but it also provides an indictor of the ability of the material to ﬂow under pressure at a speciﬁc temperature (Scheirs, 2000). Biopolymer compounding on a twin-screw extruder with masterbatches, impact modiﬁers, ﬁllers, additives, and other polymers increases the functionality of the ﬁnal product. Twin-screw extrusion is the preferred method for compounding, but polymer processing is complicated because it is sensitive to heat and shear. It is also prone to hydrolytic degradation if moisture is present in molten polymer.
This entails that in addition to adhesion by hydration, many other mechanisms, such as hydrogen bonding and ionic interactions, might also be involved. Moreover, chitosan exhibits a pH-sensitive behavior as a weak polybase due to the large quantities of amino groups on its chain. Chitosan dissolves easily at low pHs, whereas it is insoluble at higher pHs. The mechanism of pH-sensitive swelling involves the protonation of amine groups of chitosan under low pH conditions. This property has suggested as a reason to investigate chitosan as a delivery matrix.
4). The pharmaceutical industry is moving away from sole reliance on traditional biologics and small-molecule chemical entities by adopting new know-how and capabilities that originate in other industries. Medical devices and connected solutions are gaining in importance. Combination products are an appealing choice to provide treatments not possible using traditional technologies. At the same time they permit a replenishment of the product pipeline with the potential for shorter time to market, extensions of expiring patents, or the ability to reuse biologics and drugs with novel, targeted administration for higher efﬁcacy and lower toxicity.
Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine by Giuseppe Perale, Jöns Hilborn