By Ren-Ke Li, Richard D. Weisel
Cardiac Regeneration and service, quantity reviews using biomaterials, by myself or mixed with phone remedy, in supplying tissue-engineered constructs to fix the injured center and forestall or opposite center failure.
Part one explores the diversity of biomaterials to be had for cardiac fix, together with nanomaterials and hydrogels. additional chapters discover using biomaterials to augment stem mobilephone remedy for restoring ventricular functionality and producing stem cell-modified intravascular stents. half specializes in tissue engineering for cardiac fix, together with chapters on decellularized biologic scaffolds, man made scaffolds, cellphone sheet engineering, maturation of practical cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro functions, and scientific concerns for cardiac tissue engineering. ultimately, half 3 explores vascular home improvement, together with chapters highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.
Cardiac Regeneration and service, quantity Two is complemented through an preliminary quantity protecting pathology and remedies. jointly, the 2 volumes of Cardiac Regeneration and service provide a accomplished source for clinicians, scientists, or academicians desirous about cardiac regeneration, together with these drawn to mobile treatment, tissue engineering, or biomaterials.
- Surveys the range of biomaterials on hand for cardiac fix, together with nanomaterials and hydrogels.
- Focuses on tissue engineering for cardiac fix together with scientific concerns for cardiac tissue engineering
- Explores vascular home improvement, highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
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Additional resources for Cardiac regeneration and repair: Biomaterials and tissue engineering
2013). Histologically, hydrogel injections significantly reduced collagen content within the infarct and increased cardiac muscle at the endocardium compared with controls. 5-fold higher concentration only resulted in minimal platelet activation that was not deemed as clinically significant. To assess the biocompatibility of a xenogeneic hydrogel for clinical translation, the porcine derived myocardial matrix was injected into the healthy rat myocardium. At 28 days, the hydrogel was completely degraded; later time-points revealed no observable signs of chronic inflammation and presence of spindle cells, indicating a reparative remodeling process.
There was also no difference in ejection fraction or cardiac output. Histological evaluation showed limited cellular response to the HA hydrogel, without the increased macrophage and myofibroblast infiltration that is typically seen with injected hydrogels. Building upon the HA system with tunable mechanical properties developed by Ifkovits et al. (2010), Tous et al. (2011a) further modified the hydrogels such that the degradation kinetics could be altered while maintaining similar initial mechanics.
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Cardiac regeneration and repair: Biomaterials and tissue engineering by Ren-Ke Li, Richard D. Weisel