Download Controversies in Diabetes and Pregnancy by Ulf J. Eriksson (auth.), Lois Jovanovic M.D. (eds.) PDF

By Ulf J. Eriksson (auth.), Lois Jovanovic M.D. (eds.)

ISBN-10: 1461237920

ISBN-13: 9781461237921

ISBN-10: 1461283531

ISBN-13: 9781461283539

As I learn this specified quantity on diabetes and being pregnant edited by means of Lois Jovanovic, i used to be struck by means of subject matters that run all through those gathered chapters. First, this quantity offers a great evaluation of earlier difficulties, current administration, and destiny demanding situations offered via dia­ betes in being pregnant. Orury's detailed, longitudinal event with diabetes iIi being pregnant presents the reader with a massive evaluation, as does Coetzee's dialogue of gestational diabetes. present problems-deter­ mining the etiology and prevention of congenital malformations in babies of diabetic moms (10M), evaluation of antepartum fetal , administration of pregnant sufferers with diabetic retinopathy, reputation of thyroid disorder within the pregnant diabetic lady, and realizing the multitude of metabolic sequelae saw within the 10M-are completely reviewed. ultimately, vital issues for destiny therapy and ther­ apy akin to the variation of the fetal pancreas to the disordered intra­ uterine setting frequently obvious in maternal diabetes, using fetal pan­ creatic tissue for transplantation, the applying of workout within the administration of the pregnant lady with diabetes, and the long term con­ sequences for the 10M offer a thrilling glimpse into the longer term. the second one vital subject that emerges is the severe position the matter of diabetes in being pregnant has performed in our knowing of maternal and fetal body structure. scientific observations supported by means of easy study have emphasised the function of fetal fuels in teratogenesis.

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Extra resources for Controversies in Diabetes and Pregnancy

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40. Segal S, Bernstein H (1963) Observations on cataract formation in the newborn offspring of rats fed a high-galactose diet. J Pediatr 62:363-70. 41. C1avert A, Wolff-Que not MJ, Buck P (1972) Etude de I'action embryopathique du glucose en injection intraamniotique. C R Soc BioI (Paris) 166: 1789-92. 42. Clavert A, Wolff-Que not MJ. (1973) Etude du mode d'action embryopathique du glucose en injection dans Ie Jiquide ovulaire du Lapin. C R Soc BioI (Paris) 167: 1452-4. 43. Hughes AF, Freeman FB, Fadem T (1974) The teratogenic effects of sugars on the chick embryo.

IV. Studies on the permeability of the rat placenta to I'J' insulin. Diabetes 10:383-92. 1. Malformations in Diabetic Animal Models 27 64. Widness JA, Goldman AS, Susa JB, Oh W, Schwartz R (1983) Impermeability of the rat placenta to insulin during organogenesis. Teratology 28:32732. 65. Chomette G (1955) Entwicklungsstornungen nach Insulinschock beim trachtigen Kaninchen. Beitr Pathol Anat 115:439-51. 66. Brinsmade A, Buchner F, Rubsaamen H (1956) Missbildungen am Kaninchenembryo durch Insulininjektion beim Mettertier.

The experimental conditions used to study this problem may not have been always ideal, since it is known that B-cells, even though mature, do not respond to continuous stimulation by glucose as well as they do to intermittent stimulation by a mixture of glucose and amino acids (23,24). This is especially so in the presence of a secretagogue produced by the placenta (25) and in the presence of an active enteroinsular axis (26--28). Finally, it is also possible that this "insufficiency" may not be as severe as the presumed delay in the maturation of the insulinogenic response might imply, since some of the metabolic and growth-promoting functions of insulin may be performed by the fetal pituitary growth hormone or by insulin-like growth factors produced by the placenta (29-36).

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Controversies in Diabetes and Pregnancy by Ulf J. Eriksson (auth.), Lois Jovanovic M.D. (eds.)

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