Download Drug Absorption Studies: In Situ, In Vitro and In Silico by Carsten Ehrhardt, Kwang-Jin Kim PDF

By Carsten Ehrhardt, Kwang-Jin Kim

ISBN-10: 0387749004

ISBN-13: 9780387749006

Within the final 15 years, loads of mobilephone- or tissue-based in vitro versions were brought into the biopharmaceutics area. those types mimic different organic boundaries drug has to beat to ultimately achieve its objective organ/cell/receptor. those in vitro versions were came across very valuable in not just characterising the permeability behaviour of substances molecules in epithelial and endothelial tissues, but in addition learning drug supply structures for enhanced supply and more suitable absorption. in comparison to the complicated in vivo scenario, in vitro versions provide a quick, handy procedure with expense merits such a lot of occasions. most significantly, they are often standardised and automatised to be acceptable to the high-throughput screening.Starting on the molecular point of experiences, carrying on with with mobilephone monolayer versions (both basic and mobile traces) and in situ suggestions as a last checking out layout, the booklet presents a pragmatic method of modern in vitro thoughts for drug absorption stories. moreover, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory matters are lined, giving a entire evaluate of accessible types and methods. in addition, an appendix comprised with a few useful protocols is on hand on-line, up to date as wanted, should still end up very precious to use the thoughts on to the benchside.

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Extra info for Drug Absorption Studies: In Situ, In Vitro and In Silico Models

Sample text

Skin Irritation and Corrosion Any application of substances onto the skin, for instance, cosmetic products, must not cause damage to human health when applied under normal conditions. Therefore, any compound considered for application on human skin needs to be tested for reversible disadvantageous effects (skin irritation) and irreversible skin damage (skin corrosion). To test the irritancy potential of substances, two tests which can reliably distinguish between skin corrosives and noncorrosives are endorsed by the European Centre for the Validation of Alternative Methods (ECVAM).

A. Walters, and A. C. Watkinson. Methods for studying percutanous absorption. In K. A. ), Dermatological and Transdermal Formulations, Vol. , New York, 2002, pp. 197–269. 41. -X. -R. Denet, B. Vroman, P. Clarys, A. Barel, R. Verbeeck, and V. Préat. In vivo tolerance assessment of skin after insertion of subcutaneous and cutaneous microdialysis probes in the rat. Skin Pharmacol. Physiol. 16: 18–27 (2003). 42. -X. Mathy, C. Lombry, R. Verbeeck, and V. Préat. Study of percutaneous penetration of flubiprofen by cutaneous and subcutaneous microdialysis after iontophoretic delivery in rat.

Pharm. Res. 17: 1475–1481 (2000). 65. F. -H. -M. Lehr, and U. F. Schaefer. TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing. Eur. J. Pharm. Biopharm. 63: 44–50 (2006). 66. J. M. Haigh and E. W. Smith. The selection and use of natural and synthetic membranes for in vitro diffusion experiments. Eur. J. Pharm. Sci. 2: 311–330 (1994). 67. R. C. Scott, M. A. Corrigan, F. Smith, and H.

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Drug Absorption Studies: In Situ, In Vitro and In Silico Models by Carsten Ehrhardt, Kwang-Jin Kim

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