Download Drug Determination in Therapeutic and Forensic Contexts by Roger P. Maickel (auth.), Eric Reid, Ian D. Wilson (eds.) PDF

By Roger P. Maickel (auth.), Eric Reid, Ian D. Wilson (eds.)

ISBN-10: 1461294622

ISBN-13: 9781461294627

ISBN-10: 1461323975

ISBN-13: 9781461323976

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Extra resources for Drug Determination in Therapeutic and Forensic Contexts

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For lysergic acid diethylamide (LSD), confirmation relies on RIA. If positive, HPLC may be performed, with collection of fractions to be analyzed again by RIA; positive results should be obtained in fractions corresponding to the retention volume of LSD [8]. Acidic drugs can be identified in blood specimens using HPLC or GC. ), and mix; - apply to Extrelut column, leave 2 min, and elute with 2 ml of dichloromethane; evaporate to dryness; - reconstitute in 25 ~l dichloromethane, and apply 3 ~l to the GC column.

2H7 VPA (VPA-D-4; III) for pharmacokinetic studies, and [2H 7 ]VPA (VPA-D-7; IV) as i. s. for MS-CI. E. von Unruh et al. [A-3 gave more interferences with this type of label. s. (Fig. ] 3. Which isotope should serve as the label ? The elemental formula indicates which isotopes can be used. As every organic molecule contains hydrogen and carbon, deuterium (2H) and 13 C may serve as examples; the arguments for or against 15N, 170, 180 and other isotopes are similar. Deuterium is always the first choice.

1977) 1. Forensic Sci. Soc. 17, 189-194. 15. Dunnett, N. & Ashton, P. ), Croom Helm, London, pp. 272-278. 16. , von Meyer, 1. & Drasch, G. ), University of Thessaloniki, Greece, pp. 376-382. 1. E. von Unruh, M. J. Dengler Medizinische Universitatsklinik Bonn Sigmund-Freud-Str. 25 D-5300 Bonn 1, W. (1) Stable isotope dilution: 'analytical' internal standard. (2) Administration of labelled drug alone. (3) Co-administration of unlabelled and labelled forms of a drug - 'biological' internal standard.

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Drug Determination in Therapeutic and Forensic Contexts by Roger P. Maickel (auth.), Eric Reid, Ian D. Wilson (eds.)


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