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By Prof. Dr. Dr. H. Gerhard Vogel (auth.), Prof. Dr. Dr. H. Gerhard Vogel, Prof. Dr. Wolfgang H. Vogel, Prof. Dr. Bernward A. Schölkens, Prof. Dr. Jürgen Sandow, PD Dr. Günter Müller, Dr. Wolfgang F. Vogel (eds.)

ISBN-10: 3540298371

ISBN-13: 9783540298373

ISBN-10: 3540423966

ISBN-13: 9783540423966

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Additional resources for Drug Discovery and Evaluation: Pharmacological Assays Second Completely Revised, Updated, and Enlarged Edition

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1024 1024 1025 1026 1028 1028 1030 1033 1034 Inhibition of polysaccharide degrading enzymes . . . . . . . . General considerations . . . . . . . . . . . . . . . . . . . . . . . . . . Inhibition o f ¢x-amylase in vitro . . . . . . . . . . . . . . . . . . . . . 8 Contents Inhibition of glucosidase in vitro ....................................... Evaluation o f ¢x-glucosidase inhibitors u s i n g the everted sac t e c h n i q u e . .

5 General considerations on cholesterol biosynthesis . . . . . . . . D e t e r m i n a t i o n o f H M G - C o A - r e d u c t a s e inhibitory activity ....... General considerations on H M G - C o A reductase . . . . . . . . . . Inhibition of the isolated e n z y m e H M G - C o A - r e d u c t a s e in vitro ... Inhibition o f the incorporation of 14C sodium acetate into cholesterol in isolated liver cells . . . . . . . . . . . . . . . . . . . .

3T3 A d i p o c y t e s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Lipogenesis assay ............................................................ Assays of glucose transport ................................................ Adipocyte plasma membranes ............................................ Effect on glucose transporter translocation ............................. Influence on further metabolic functions ...............................

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Drug Discovery and Evaluation: Pharmacological Assays Second Completely Revised, Updated, and Enlarged Edition by Prof. Dr. Dr. H. Gerhard Vogel (auth.), Prof. Dr. Dr. H. Gerhard Vogel, Prof. Dr. Wolfgang H. Vogel, Prof. Dr. Bernward A. Schölkens, Prof. Dr. Jürgen Sandow, PD Dr. Günter Müller, Dr. Wolfgang F. Vogel (eds.)


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