Download Drug-Induced Liver Disease by Neil Kaplowitz, Laurie D. DeLeve PDF

By Neil Kaplowitz, Laurie D. DeLeve

ISBN-10: 0849398967

ISBN-13: 9780849398964

Epidemiological reports have discovered that medications at the moment are the most typical reason for liver failure within the usa, and the prior decade has obvious an explosion of latest info in regards to the immunology, toxicology, and pharmacology of drug-induced liver affliction. This expertly written moment version provides an in-depth dialogue of the hot advancements in drug-induced hepatotoxicity, protecting mechanisms, histopathology, administration, probability elements, and styles of drug and toxin-induced liver ailment.

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Yoshioka T, Krauser JA, Guengerich FP. Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine. Chem Res Toxicol 2002; 15(8):1096–105. 57. Guengerich FP, Liebler DC. Enzymatic activation of chemicals to toxic metabolites. CRC Crit Rev Toxicol 1985; 14(3):259–307. 58. Johnson WW, Harris TM, Guengerich FP. Kinetics and mechanism of hydrolysis of aflatoxin B1 exo-8,9oxide and rearrangement of the dihydrodiol. J Am Chem Soc 1996; 118(35):8213–20. 59. Guengerich FP, Arneson KO, Williams KM, et al.

TCE oxide [and its rearrangement product(s)] does not react well with DNA (75). The reactions with protein lysine groups yield stable amides, both N6-formyl lysine and N6dichloroacetyl lysine (55). Modern electrospray mass spectrometry methods can be used to quantify the number and amount of the two adducts formed on an oligopeptide or small protein in vitro (55). In the course of such analysis, it was found that some of the adducts are unstable at basic or neutral pH (75). These appear to be adducts formed with serine, cysteine, and tyrosine (75).

32. Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, et al. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Drug Metab Dispos 1997; 25(11):1228–33. 33. Watkins PB. Omeprazole induction of cytochrome P-450IA2: the importance of selecting the appropriate human model. Hepatology 1993; 17(4):748–50. 34. , Jensen JPA, et al. Cancer among epileptic patients exposed to anticonvulsant drugs. J Natl Cancer Inst 1989; 81(10):803–8. 35. Capen CC, Dayan AD, Green S. Receptor-mediated mechanisms in carcinogenesis: an overview.

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Drug-Induced Liver Disease by Neil Kaplowitz, Laurie D. DeLeve


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