By Neil Kaplowitz, Laurie D. DeLeve
Epidemiological reports have discovered that medications at the moment are the most typical reason for liver failure within the usa, and the prior decade has obvious an explosion of latest info in regards to the immunology, toxicology, and pharmacology of drug-induced liver affliction. This expertly written moment version provides an in-depth dialogue of the hot advancements in drug-induced hepatotoxicity, protecting mechanisms, histopathology, administration, probability elements, and styles of drug and toxin-induced liver ailment.
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TCE oxide [and its rearrangement product(s)] does not react well with DNA (75). The reactions with protein lysine groups yield stable amides, both N6-formyl lysine and N6dichloroacetyl lysine (55). Modern electrospray mass spectrometry methods can be used to quantify the number and amount of the two adducts formed on an oligopeptide or small protein in vitro (55). In the course of such analysis, it was found that some of the adducts are unstable at basic or neutral pH (75). These appear to be adducts formed with serine, cysteine, and tyrosine (75).
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Drug-Induced Liver Disease by Neil Kaplowitz, Laurie D. DeLeve